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  • Title: Inhibition of 3H-glibenclamide binding to sulfonylurea receptors by oral antidiabetics.
    Author: Geisen K, Hitzel V, Okomonopoulos R, Pünter J, Weyer R, Summ HD.
    Journal: Arzneimittelforschung; 1985; 35(4):707-12. PubMed ID: 3925960.
    Abstract:
    Specific binding of 3H-glibenclamide (HB 419) is observed with membranes from rat cerebral cortex and rat beta-cell tumor. 3H-Glibenclamide binding is of high affinity, reversible, saturable, and can be displaced by oral antidiabetics of different structural types. Half maximal inhibition of binding correlates with the hypoglycemic action of the compounds.
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