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  • Title: The effects of arotinoids on rat mammary carcinogenesis.
    Author: Hartmann HR, Bollag W.
    Journal: Cancer Chemother Pharmacol; 1985; 15(2):141-3. PubMed ID: 3926332.
    Abstract:
    The influence of two retinoids, Ro 13-6298, an arotinoid ethyl ester, and Ro 15-1570, an arotinoid ethyl sulfone, on rat mammary carcinogenesis was investigated. Mammary carcinomas were induced by oral administration of 15 mg dimethylbenz(a)anthracene (DMBA) to 50-day-old female Sprague-Dawley rats. Oral administration of the two retinoids significantly inhibited the development of tumors. The number and volume of mammary neoplasms were influenced in a dose-dependent manner.
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