These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Involvement of Ca2+ in platelet-derived growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts.
    Author: Tsuda T, Kaibuchi K, West B, Takai Y.
    Journal: FEBS Lett; 1985 Jul 22; 187(1):43-6. PubMed ID: 3926536.
    Abstract:
    Addition of platelet-derived growth factor (PDGF) to quiescent cultures of Swiss 3T3 fibroblasts rapidly increased the cytoplasmic free Ca2+ concentrations and afterwards the c-myc mRNA levels. The concentrations of PDGF needed for both reactions were roughly the same. Moreover, the Ca2+ ionophores, A23187 and ionomycin, mimicked the actions of PDGF and increased the c-myc mRNA levels. These results suggest that Ca2+ may be involved in the regulation of PDGF-induced expression of the c-myc gene.
    [Abstract] [Full Text] [Related] [New Search]