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  • Title: The bursa of Fabricius: a trapping site for environmental antigens.
    Author: Ekino S, Suginohara K, Urano T, Fujii H, Matsuno K, Kotani M.
    Journal: Immunology; 1985 Jul; 55(3):405-10. PubMed ID: 3926634.
    Abstract:
    The entry of environmental antigens into the lumen of the bursa of Fabricius was prevented by ligating the bursal duct prior to hatching (BDL: bursal duct ligation). The development of 'natural' serum agglutinins for bacteria and heteroerythrocytes was markedly suppressed by BDL. The antigen-specific recovery was observed by simultaneous administration of sterile antigens into the bursal lumen at the time of BDL. These results strongly suggest that the bursa of Fabricius is a major channel through which environmental antigens stimulate the immune system and induce the formation of 'natural' serum agglutinins.
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