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  • Title: Auditory and vestibular function in hyperbaric oxygen.
    Author: Marsh RR, Lambersten CJ, Schwartz DM, Clark JM, Wetmore RF.
    Journal: Otolaryngol Head Neck Surg; 1985 Jun; 93(3):390-3. PubMed ID: 3927236.
    Abstract:
    The therapeutic value of high partial pressures of oxygen is limited by the toxicity of oxygen. Pulmonary damage, visual impairment, and convulsions are known hazards during hyperoxic exposure, but dose-effect relationships have not been quantified for specific organs or functions. As part of an integrated study of organ oxygen tolerance in man (Predictive Study V of the Institute for Environmental Medicine), auditory and vestibular function was evaluated in man before, during, and after exposure to 100% oxygen at 3 atmospheres absolute pressure for 2 to 3.5 hours. No alterations in hearing or equilibrium were detected, suggesting that ototoxicity is not a factor that would limit exposure under these conditions.
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