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  • Title: The importance of brain serotonergic receptor mechanisms for the action of antidepressant drugs.
    Author: Ogren SO, Fuxe K, Agnati L.
    Journal: Pharmacopsychiatry; 1985 Mar; 18(2):209-13. PubMed ID: 3927330.
    Abstract:
    The present studies have shown that chronic antidepressant treatment with different types of antidepressant drugs results in adaptive changes in postsynaptic 5-HT receptor mechanisms which appear to result in 5-HT sub- or supersensitivity development depending upon the 5-HT nerve terminal system analyzed. The results underline the heterogeneity of the central 5-HT neuron systems in their responses to chronic antidepressant treatment. In addition, a number of antidepressant drugs have potent, direct actions on 5-HT2 receptors, which may be of clinical relevance.
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