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  • Title: Multiple myeloma in three siblings.
    Author: Horwitz LJ, Levy RN, Rosner F.
    Journal: Arch Intern Med; 1985 Aug; 145(8):1449-50. PubMed ID: 3927866.
    Abstract:
    All three siblings of a family developed multiple myeloma. Two siblings had a history of monoclonal gammopathy; in one of these two siblings and in the third sibling, the disease progressed rapidly. A review of the literature shows that of 38 previously reported pairs of siblings with plasma cell disorders, eight families had a third affected sibling and four another affected relative. This clinical clustering suggests that some cases of multiple myeloma may have a hereditary basis and that other family members may be at risk for developing the disease.
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