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  • Title: Endothelial cell proliferation in myelofibrosis.
    Author: Reilly JT, Nash JR, Mackie MJ, McVerry BA.
    Journal: Br J Haematol; 1985 Aug; 60(4):625-30. PubMed ID: 3927969.
    Abstract:
    The distribution of laminin and collagen type IV in normal human bone marrow appeared to be limited to a small number of capillary and sinusoidal basement membranes. Cellular elements including megakaryocytes showed a negative staining reaction. In contrast, myelofibrotic bone marrow showed markedly increased quantities of both laminin and collagen type IV. This was consistent with a proliferation of endothelial cells within the marrow as confirmed by factor VIII RAG staining. It is suggested that in myelofibrosis in addition to a marked fibrous reaction proliferation of vascular elements is also prominent.
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