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  • Title: Modified smear method for screening potential inhibitors of platelet aggregation from plant sources.
    Author: Yun-Choi HS, Kim SO, Kim JH, Lee JR, Cho HI.
    Journal: J Nat Prod; 1985; 48(3):363-70. PubMed ID: 3928819.
    Abstract:
    The smear method developed by Velaskar and Chitre was modified to allow the massive screening of plant extracts and/or fractions for platelet antiaggregating activity. Aspirin and papaverine, known inhibitors of platelet aggregation, were tested by the modified method and showed comparable results with previously reported data. Fifty-four fractions prepared from eighteen plant species were screened for their inhibitory effects on adenosine 5'-diphosphate, arachidonic acid, or collagen-induced rat platelet aggregation. The results suggest that plants could be a potential source of inhibitors of platelet aggregation.
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