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  • Title: Prophylactic antimicrobials in elective colorectal and biliary surgery.
    Author: Perrott CA, Hinder RA, Cassel R, Koornhof HJ, Naude G, Kleinman M, Taubin A, Becker P, Myburgh JA.
    Journal: S Afr Med J; 1985 Sep 14; 68(6):387-91. PubMed ID: 3929402.
    Abstract:
    In 97 patients undergoing elective biliary (44) or colorectal (53) surgery, cases were randomly allocated to receive peri-operative prophylaxis with either cefoxitin (Mefoxin; MSD) or metronidazole, penicillin and tobramycin (MPT). Sepsis occurred in 3 of the biliary cases (6,8%) and in 16 of the colorectal cases (30,2%). In the colorectal group sepsis occurred equally in patients receiving cefoxitin (22,2%) or MPT (38,5%) (P = 0,20). Patients who developed sepsis did not have a prolonged hospital stay; strict criteria were used to define sepsis in this study and this explains the apparently high sepsis rate. A positive wound culture at the end of the operation was more common after colorectal surgery (30,2%) than after biliary surgery (4,6%) and was associated with a higher subsequent infection rate (P = 0,02).
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