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  • Title: Ornithine decarboxylase inhibitors increase the cellular content of the enzyme: implications for translational regulation.
    Author: Persson L, Oredsson SM, Anehus S, Heby O.
    Journal: Biochem Biophys Res Commun; 1985 Aug 30; 131(1):239-45. PubMed ID: 3929778.
    Abstract:
    Ehrlich ascites tumor cells grown in the presence of inhibitors of ornithine decarboxylase (EC 4.1.1.17) exhibited an elevated content of this enzyme. The increase could not solely be explained by a decrease in the degradation rate of the enzyme. Instead a stimulation of enzyme synthesis, probably mediated via the polyamine-depleting properties of the inhibitors, is suggested. The enhancement of cellular ornithine decarboxylase content was not accompanied by any significant changes in the amount of ornithine decarboxylase mRNA, indicating a regulation at the level of translation.
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