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  • Title: Pertussis toxin inhibits intracellular pH changes in human neutrophils stimulated by N-formyl-methionyl-leucyl-phenylalanine.
    Author: Satoh M, Nanri H, Takeshige K, Minakami S.
    Journal: Biochem Biophys Res Commun; 1985 Aug 30; 131(1):64-9. PubMed ID: 3929781.
    Abstract:
    Changes of intracellular pH in human neutrophils were monitored by 9-aminoacridine fluorescence. Both initial acidification and subsequent alkalinization phases induced by a chemotactic peptide, N-formyl-methionyl-leucyl-phenylalanine were dependent on the extracellular Ca2+-concentrations, and a calcium ionophore, A-23187 similarly induced the pH-changes. Pertussis toxin inhibited the pH-changes induced by the peptide while cholera toxin did not. The pH-changes induced by A-23187 were not affected by the toxins. The results suggest that the inhibitory guanine-nucleotide regulatory protein and Ca2+ are involved in the pH-changes induced by the peptide.
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