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  • Title: Localized retroperitoneal mass suspected malignancy: A rare case of unicentric Castleman's disease.
    Author: Alhariry ES, Hasan A, Abdelghany A, Nafie K.
    Journal: Clin Case Rep; 2024 Sep; 12(9):e9451. PubMed ID: 39301097.
    Abstract:
    KEY CLINICAL MESSAGE: Castleman's Disease should be considered in the differential diagnosis of retroperitoneal masses, especially in equivocal cases. Clinician should not presume all cases of retroperitoneal masses as a malignancy. ABSTRACT: Castleman's Disease is a heterogeneous group of lymphoproliferative disorders, that can develop in lymph nodes or in extranodal sites. It has three distinct histological subtypes; hyaline vascular, plasma cell or mixed. It can be unicentric or multicentric, and sometimes oligocentric or regional. In this article, we report a case of a 30-year-old male who presented with a palpable left lumbar mass, clinically suspected as sarcoma vs GIST, which was surgically excised and pathologically examined revealing a rare condition of intra-abdominal unicentric Castleman's Disease with good prognosis. Castleman's Disease should be considered in the differential diagnosis of retroperitoneal masses, especially in equivocal cases.
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