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Title: Breakage on chromosome 2 brings the Ck gene to a region 3' of c-myc in a Burkitt's lymphoma line carrying a (2;8) translocation. Author: Malcolm S, Davis M, Rabbitts TH. Journal: Cytogenet Cell Genet; 1985; 39(3):168-72. PubMed ID: 3930155. Abstract: We have shown using in situ hybridization that the constant region of the kappa light chain immunoglobulin gene (Ck) is translocated from chromosome 2 to chromosome 8 in Burkitt's lymphoma cells with a (2;8) translocation. The Ck gene then ends up adjacent to and on the 3' side of c-myc. The breakpoint probably falls between the gene for the variable region of the kappa light chain (Vk) and the Ck gene.[Abstract] [Full Text] [Related] [New Search]