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  • Title: I-J expression is not associated with murine chromosome 4.
    Author: Waltenbaugh C, Sun L, Lei HY.
    Journal: Eur J Immunol; 1985 Sep; 15(9):922-6. PubMed ID: 3930262.
    Abstract:
    I-J originally mapped within the murine major histocompatibility complex (H-2) between the EB and Ea loci using intra-H-2 recombinants. Cloning of this segment of H-2 shows no DNA that can be ascribed to I-J. Various hypotheses have attempted to explain this dilemma. One hypothesis attributes a chromosome 4 locus with I-Jk expression. This hypothesis requires the AKR/J and A/WySn mouse strains to be I-Jk negative. In the present report we show that AKR/J spleen cells express I-Jk surface molecules and that both the AKR/J and A/WySn mouse strains produce functional I-Jk-bearing suppressor factors to poly(Glu50Tyr50). Our data imply that mapping of I-J-determining genes to chromosome 4 may be premature.
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