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  • Title: Covalent binding of aflatoxin B1 to liver DNA in rats pretreated with ethanol.
    Author: Marinovich M, Lutz WK.
    Journal: Experientia; 1985 Oct 15; 41(10):1338-40. PubMed ID: 3930282.
    Abstract:
    Male Fischer F-344 rats were given ethanol in the drinking water and/or by single oral administration. Following this, the animals received p.o. 100 ng/kg of the hepatocarcinogen [3H]aflatoxin B1 (AFB1). 24 h later, the level of DNA-bound AFB1 was determined in the liver and was found not to be affected by any type of ethanol pretreatment. A cocarcinogenic effect of ethanol in the liver is therefore unlikely to be due to an effect on the metabolic activation inactivation processes governing the formation of DNA-binding AFB1 metabolites.
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