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  • Title: Benzodiazepines alter acquisition and retention of an inhibitory avoidance response in mice.
    Author: Jensen RA, Martinez JL, Vasquez BJ, McGaugh JL.
    Journal: Psychopharmacology (Berl); 1979 Jun 28; 64(1):125-6. PubMed ID: 39313.
    Abstract:
    These experiments were performed to examine the effects of graded doses of diazepam, flurazepam, or lorazepam given to Swiss-Webster mice either 30 min prior to training or immediately after training in a one-trial inhibitory (passive) avoidance task. A 350 MUA footshock was administered following entry into a darkened compartment and retention was tested three days later. Doses of 10.0 mg/kg diazepam and 20.0 mg/kg lorazepam given before training significantly impaired acquisition, while 1.0 mg/kg flurazepam, given immediately after training, produced retrograde amnesia. These results indicate that benzodiazepines affect memory processes and that various drugs of the benzodiazepine family differentially affect acquisition and memory consolidation.
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