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  • Title: [The suitability of propylene glycol (1,2-propanediol) as an active antimicrobial adjuvant in ointments].
    Author: Bäurle G, Bieber S, Hornstein OP, Nürnberg E, Muckenschnabel R.
    Journal: Z Hautkr; 1985 Aug 01; 60(15):1198-213. PubMed ID: 3931367.
    Abstract:
    Propylene glycol was tested for its antimicrobial activity as well as its possible irritant effect in ointments. With regard to the antimicrobial effect, vehicles containing more than 5% propylene glycol proved to be superior to those containing glycerol. 269 volunteers with or without eczema who had been treated with 10% propylene glycol under occlusion and by means of the Duhring chamber method, showed very few irritations; there was almost none observed in patients tested with an ointment containing glycerol instead. We did not find any allergic sensitization against propylene glycol.
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