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  • Title: [Hypotension induced by molsidomine or trinitroglycerin].
    Author: Dassier P, Blanloeil Y, Pinaud M, Bodin D, Vandeville B.
    Journal: Cah Anesthesiol; 1985; 33(4):309-13. PubMed ID: 3931864.
    Abstract:
    Molsidomine--a new vasodilator agent with predominant venous effect--is used for the treatment of coronary artery disease. Haemodynamic effects of i.v. molsidomine (300 micrograms X kg-1) during deliberate hypotension were investigated in 11 dogs and compared with nitroglycerin-induced-hypotension, at the same decrease in MAP (-25%). Hypotension was only obtained in 5 dogs with both drugs. Hypotension resulted from decrease in stroke volume due to a decrease in preload. Decrease in systemic vascular resistance and tachycardia were less important with molsidomine than with nitroglycerin. After molsidomine MAP decreased progressively over 30 minutes.
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