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  • Title: Properties of volkensin, a toxic lectin from Adenia volkensii.
    Author: Stirpe F, Barbieri L, Abbondanza A, Falasca AI, Brown AN, Sandvig K, Olsnes S, Pihl A.
    Journal: J Biol Chem; 1985 Nov 25; 260(27):14589-95. PubMed ID: 3932357.
    Abstract:
    Volkensin, a highly toxic protein from the roots of Adenia volkensii (kilyambiti, kinoria), was purified by affinity chromatography on acid-treated Sepharose 6B. The toxin is a glycoprotein (Mr 62,000, neutral sugar content 5.74%) consisting of an A subunit (Mr 29,000) and of a B subunit (Mr 36,000) linked by disulfide and noncovalent bond(s). The amino acid, amino sugar, and neutral sugar composition of the protein were determined. Volkensin is a galactose-specific lectin and is a potent inhibitor of eukaryotic protein synthesis in whole cells as well as in a cell-free system (a rabbit reticulocyte lysate). The inhibitory and the lectin activities are functions of the A and B subunits, respectively. Volkensin can be included amongst the ricin-like toxins and resembles most closely modeccin, the toxin of Adenia digitata.
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