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  • Title: 12-O-tetradecanoylphorbol-13-acetate promotes tumors prior to initiation in two-stage promotion.
    Author: Ordman AB, Cleaveland JS, Boutwell RK.
    Journal: Cancer Lett; 1985 Oct; 29(1):79-84. PubMed ID: 3933814.
    Abstract:
    The tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and the non-promoter mezerein both induce ornithine decarboxylase activity in mouse epidermis by a route which can be blocked by indomethacin. In two-stage tumor promotion experiments in mice with mezerein as the stage II promoter, TPA was effective as the stage I promoter whether it was applied before or after an initiating dose of 7,12-dimethylbenz[a]anthracene (DMBA). There appear to be at least 4 events in promotion, only 3 of which are caused by second stage promoters.
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