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  • Title: Stimulation by glucose and carbamylcholine of phospholipase A2 in pancreatic islets.
    Author: Mathias PC, Best L, Malaisse WJ.
    Journal: Diabetes Res; 1985 Sep; 2(5):267-70. PubMed ID: 3933882.
    Abstract:
    Glucose, in high concentrations (16.7-27.8 mM), caused a modest increase in effluent radioactivity from rat pancreatic islets prelabelled with [U-14C] arachidonate. The response to glucose was abolished in the absence of extracellular Ca2+. At a low glucose concentration (5.6 mM), carbamylcholine (1.0 mM) provoked a more marked and sustained increase in effluent radioactivity. The response to the cholinergic agent was abolished in the presence of atropine or absence of extracellular Ca2+. These results suggest that carbamylcholine and, to a lesser extent, glucose cause a Ca2+-dependent activation of phospholipase A2 in intact islet cells.
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