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  • Title: Effect of beta-endorphin on calcium uptake in the brain.
    Author: Guerrero-Munoz F, de Lourdes Guerrero M, Way EL, Li CH.
    Journal: Science; 1979 Oct 05; 206(4414):89-91. PubMed ID: 39340.
    Abstract:
    The uptake of 45Ca2+ by nerve-ending fractions from brains of mice was inhibited in vitro by 10(-9)M concentrations of beta-endorphin and in mice injected intraventricularly with 7 picomoles of beta-endorphin. That the effect was a specific opiate agonist response of beta-endorphin was demonstrated by use of the opiate antagonist, naloxone, which reversed the action. A role for beta-endorphin in the regulation of calcium flux and neurotransmitter release should be considered.
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