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  • Title: Multirod posterior occipitocervical instrumentation constructs: a biomechanical analysis and initial case series of 10 patients with complex craniocervical pathology.
    Author: Collins AP, Mumtaz M, Tripathi S, Varier SK, Turner AW, Clark AJ, Goel VK, Theologis AA.
    Journal: Spine J; 2024 Sep 28; ():. PubMed ID: 39343239.
    Abstract:
    BACKGROUND CONTEXT: Stabilization of the occipitocervical (OC) junction with posterior instrumentation plays a vital role in addressing a spectrum of pathologies. Due to limited bone surfaces of the occiput and C1 lamina, achieving union across the OC junction is challenging. PURPOSE: To explore the biomechanics and a clinical series of patients treated with multirod constructs across the OC junction using a novel occipital plate with single- and dual-headed, modular tulip heads. STUDY DESIGN/SETTING: Biomechanical analysis and retrospective case series. PATIENT SAMPLE: Adults at a single institution who underwent posterior cervical multirod constructs across the OC junction. OUTCOME MEASURES: OC-C4 range of motion (ROM), maximum von Mises stress on the rods, and adjacent segment ROMs and intradiscal parameters. Patient demographics, revision operations, rod breakages, wound complications. METHODS: A validated occiput-cervical finite element (FE) model was used to simulate OC-C4 cervical fixation under multidirectional pure moment loading. A total of 4 rod configurations were simulated: (A) 2-rod-Ti (4.0 mm titanium rods); (B) 2-rod-CoCr (3.5 mm cobalt chrome rods); (C) 3-rods (4.0 mm titanium rods); (D) 4-rods (4.0 mm titanium rods). The aforementioned measures were compared. A retrospective analysis was also performed of adults at a single institution who underwent posterior cervical multirod constructs across the OC junction. RESULTS: Biomechanically, lowest primary rod stresses were observed for 3- and 4-rod constructs. Compared to 2-rod-Ti (121.8 MPa), 2-rod-CoCr showed a 43.2% stress increase in the rods, while 3- and 4-rods experienced rod stress reductions of 20% and 23.2%, respectively. No appreciable differences in OC-C4 ROM, C4-5 ROM, and C4-5 discal stresses were found between multirod and 2-rod constructs. Maximum occipital and C4 screw stresses were decreased in multirod constructs compared to 2-rods, with least stresses noted in the 4-rod construct. Maximum plate stresses were slightly increased in the 4-rod construct compared to 2- and 3-rod fixation, though the forces were largely similar among the constructs. Ten patients (average age 66.4±10.6 years; 8 males) were assessed clinically. Nine of the ten operations were for primary stabilization of pathological fractures and associated craniocervical and/or atlantoaxial instability using 4-rods across the OC junction. At an average follow-up time of 1.58±0.5 years (range, 1-2.3 years), there were no instrumentation failures, no adjacent segment failures, and no wound complications. CONCLUSIONS: In this proof-of-concept investigation, multiple rods (3- and 4-rods) across the OC junction using a novel occipital plate with single- and dual-headed, modular tulips was safe and effective in stabilizing the OC junction. Accompanying FE analysis demonstrated that multirod constructs decreased primary rod stresses and had lower stresses on occipital and C4 screws compared to 2-rod constructs, while occipital plate stresses were largely similar. Additional clinical studies are needed to confirm these findings and to determine the ultimate utility of multirod constructs across the OC junction.
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