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  • Title: KF4939, a new anti-platelet agent, inhibits activation of phospholipase C and A2 in rabbit platelets.
    Author: Yamada K, Kumada Y, Kubo K.
    Journal: Jpn J Pharmacol; 1985 Sep; 39(1):108-11. PubMed ID: 3934441.
    Abstract:
    Effect of KF4939 on activation of phospholipase C and A2 was examined by using rabbit platelets prelabelled with [14C]-arachidonic acid. The results showed that KF4939 inhibited the activation of the two phospholipases, separately. The inhibition of phospholipase C activation is thought to be a possible mechanism of KF4939 to inhibit aggregation and secretion which are independent of the synthesis of cyclooxygenase products such as thromboxane A2.
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