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  • Title: Vernolepin: an antiplatelet compound of natural origin.
    Author: Laekeman GM, De Clerck F, Vlietinck AJ, Herman AG.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1985 Oct; 331(1):108-13. PubMed ID: 3934564.
    Abstract:
    Vernolepin, a natural compound isolated from Vernonia amygdalina Del., shows platelet anti-aggregating properties. In this paper some of its pharmacological activities towards rabbit platelets are studied. Vernolepin has a "stabilizing" effect during freeze-thawing of platelets, it inhibits arachidonic acid, ADP and collagen-induced platelet aggregation and interferes with ATP-release. Electromicroscopy shows a protection of platelets by the drug against adhesion and a desaggregating effect. All these activities are time dependent; a steep dose response relationship is seen. A concentration of 1 X 10(-5) g/ml seems to be optimal.
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