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  • Title: A turn-on fluorescent aptasensor for Pb2+ detection based on rhodamine B dye leakage from the internal cavity of hollow gold nanoparticles.
    Author: Hassibian S, Esmaelpourfarkhani M, Abnous K, Amin M, Ghazvinian F, Alibolandi M, Ramezani M, Nameghi MA, Mollasalehi H, Farrokhi N, Dehnavi SM, Taghdisi SM.
    Journal: Food Chem; 2025 Jan 15; 463(Pt 4):141440. PubMed ID: 39348770.
    Abstract:
    In this project, a sensitive fluorescent aptasensor was fabricated to detect lead ions (Pb2+) by applying hollow gold nanoparticles (HGNPs) as a nano-carrier and rhodamine B (RDB) fluorescent dye as the signal agent. In the aptasensor that was created, the specific attachment of the aptamers to Pb2+ ions led to the release of aptamer from the chitosan (CTS) coated-HGNPs loaded with RDB, causing an increase in fluorescence intensity due to the leakage of RDB. The method demonstrated specific detection of the target analyte, achieving a detection limit (LOD) of 1 ppb and a broad linear dynamic range spanning from 2 to 1000 ppb. The aptasensor was able to accurately measure the concentration of Pb2+ in human serum, low-fat milk, and mineral water samples. The suggested biosensor, which offers the benefits of simplicity, user-friendliness, affordability, and high sensitivity, is well-suited for use with complex samples such as environmental and clinical samples.
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