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  • Title: Prostacyclin production and lipid peroxidation in the aorta of rats fed with cholesterol autoxidation products.
    Author: Martinez-Sales V, Fornas E, Camañas A.
    Journal: Artery; 1985; 12(4):213-9. PubMed ID: 3935095.
    Abstract:
    The stable metabolite of prostacyclin 6-keto PGF1 alpha originating from the (1-14C) arachidonic acid, and lipid peroxidation expressed as thiobarbituric acid-reacting substance (TBARS) were studied in the aorta of rats fed a diet enriched in 2% w/w cholesterol autoxidation products for 24 hours prior to sacrifice. A slight increase was found in the amount of TBARS as well as in the conversion of (1-14C) arachidonic acid to 6-keto PGF1 alpha. These results suggest that in aorta there exists a protection mechanism which acts to increase the production of prostacyclin.
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