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  • Title: 6-Keto-prostaglandin E1 inhibits the aggregation of human platelets.
    Author: Wong PY, McGiff JC, Sun FF, Lee WH.
    Journal: Eur J Pharmacol; 1979 Dec 07; 60(2-3):245-8. PubMed ID: 393526.
    Abstract:
    6-Keto-prostaglandin E1 (6-keto-PGE1) was found to have a similar potency to prostacyclin (PGI2) as an inhibitor of platelet aggregation. It caused a time and concentration dependent inhibition of ADP, collagen and epinephrine induced platelet aggregation, the dose ratios for 70% inhibition by 6-keto-PGE1, PGI2 and PGE1 being approximately 1 : 1 : 13. In doses similar to those of PGI2, 6-keto-PGE1 partially inhibited the release of [3H]-serotonin from platelet-rich plasma induced by collagen.
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