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  • Title: The effect of 6-hydroxydopamine and some hypotensive drugs on lypressin induced hypertension in rats.
    Author: Szadowska A, Szmigielska H, Szmigielski A, Kamińska A, Wejman I.
    Journal: Pol J Pharmacol Pharm; 1985; 37(4):487-93. PubMed ID: 3936030.
    Abstract:
    Intracerebroventricular injection of 6-hydroxydopamine (6-OH-DA) prevented the development of the lypressin (LVP)-induced hypertension. Administration of 6-OH-DA to hypertensive rats significantly decreased, but did not normalize, blood pressure. A fourteen-day treatment with clonidine, guanethidine, reserpine, dihydralazine, propranolol and furosemide produced a transient decrease in blood pressure in LVP-hypertensive rats. Eight weeks after the withdrawal of hypotensive drugs blood pressure again reached the value corresponding to that in untreated LVP-hypertensive rats.
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