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  • Title: Effect of the Tc-nitrido group on the behaviour of 99mTc-radiopharmaceuticals.
    Author: Baldas J, Bonnyman J.
    Journal: Int J Appl Radiat Isot; 1985 Dec; 36(12):919-23. PubMed ID: 3936786.
    Abstract:
    The preparation of the 99mTcN-complexes of gluconate, EHDP, HIDA and PIPIDA by substitution reactions of 99mTcNCl4- is described. Studies of the distribution of these complexes in mice indicate that the presence of the Tc-nitrido group significantly alters the biological properties of the 99mTc-complexes formed using these ligands. Results suggest that the 99mTcN-complexes of these ligands are labile and undergo some ligand exchange in vivo.
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