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  • Title: Dopamine agonists suppress visual-cortical reflex myoclonus.
    Author: Obeso JA, Artieda J, Tuñón T, Luquin MR, Martínez Lage JM.
    Journal: J Neurol Neurosurg Psychiatry; 1985 Dec; 48(12):1277-83. PubMed ID: 3936901.
    Abstract:
    Two patients with a diagnosis of olivo-ponto-cerebellar atrophy developed cortical reflex myoclonus to visual (flash) and somaesthetic stimuli. Oral treatment with levodopacarbidopa (1000/100 mg) or subcutaneous administration of apomorphine (1 mg) abolished the visually-triggered myoclonus, without modifying reflex myoclonus to electrical or tactile stimulation. Intravenous administration of lisuride (0.1 mg) produced a marked reduction in both types of reflex myoclonus. These results indicate a selective inhibitory effect of dopamine agonist drugs on visual reflex myoclonus of cortical origin.
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