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  • Title: Molecular specificity of ganglioside effects on neurite regeneration of sensory neurons in vitro.
    Author: Doherty P, Dickson JG, Flanigan TP, Leon A, Toffano G, Walsh FS.
    Journal: Neurosci Lett; 1985 Dec 04; 62(2):193-8. PubMed ID: 3937073.
    Abstract:
    Highly purified preparations of individual gangliosides have been tested for their ability to modulate the survival and morphological differentiation of embryonic chick dorsal root ganglion neurons. When added at 48 h to established cultures of nerve growth factor (NGF)-dependent neurons, all ganglioside species tested increased the expression of neurofilament protein. Poly- and trisialogangliosides were more effective than di- or monosialogangliosides. In contrast, neither NGF nor an antiserum against NGF influenced neurofilament protein expression over this period of culture. In addition, ganglioside-induced expression of neurofilament protein was not inhibited by the anti-NGF serum.
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