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  • Title: Functional changes in marrow stromal cells in aplastic anaemia.
    Author: Hotta T, Kato T, Maeda H, Yamao H, Yamada H, Saito H.
    Journal: Acta Haematol; 1985; 74(2):65-9. PubMed ID: 3937417.
    Abstract:
    To determine whether or not abnormalities exist in the bone marrow stroma in aplastic anaemia, we analysed the ability of marrow stromal cells to support haemopoiesis using a long-term culture system. Marrow stromal cell layers from 3 of 9 patients with this disorder failed to maintain granulocyte-macrophage colony-forming cells in vitro. The stromal dysfunction was reversible in 1 patient who recovered after androgen therapy. The results of the present study add to the available evidence for a functional defect of marrow microenvironments in some cases of aplastic anaemia.
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