These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Evaluation of the antihypertensive effect of capsule and tablet forms of nifedipine in moderate hypertension].
    Author: Thibonnier M, Sassano P, Corvol P.
    Journal: Arch Mal Coeur Vaiss; 1985 Nov; 78 Spec No():25-8. PubMed ID: 3937501.
    Abstract:
    The antihypertensive effect of nifedipine which has a preferential antagonistic action in the calcium channels of vascular smooth muscle was studied in several series of patients. A preliminary double-blind placebo study in 7 moderate hypertensive patients showed that a 10 mg capsule of nifedipine induced a significant fall in systolic and diastolic pressures (max. - 14%) which persisted for 3 hours in ambulatory patients. A crossover trial against captopril (1 mg/kg) in 12 moderately hypertensive patients illustrated the antihypertensive effects of 2 capsules (20 mg) of nifedipine. The onset of action was faster and the effects, which were more intense than those of captopril, lasted several hours. A double-blind crossover trial against placebo was performed with 3 doses (20, 40, 60 mg) of a tablet form of nifedipine in 8 hypertensive patients. The degree and duration of the fall in blood pressure depended on the dosage: - 11% and 7 hours with 20 mg; - 14% and 10 hours with 40 mg and - 18% and 12 hours with 60 mg. This study demonstrated a direct relationship between the plasma concentration of nifedipine and the associated fall in mean blood pressure. Finally, in a chronic study of 20 hypertensive patients receiving 2 X 20 mg daily of the tablet form of nifedipine alone for 3 weeks, an 8% fall in blood pressure was observed, normalising the values in 50% of cases. Patients who remained hypertensive were given 2 X 40 mg of the nifedipine tablets for another 3 weeks and an additional 7% fall in blood pressure was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
    [Abstract] [Full Text] [Related] [New Search]