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  • Title: Evidence for the steric proximity of Tyr 174 and Lys 111 in bovine growth hormone.
    Author: Nowicki C, Wolfenstein-Todel C, Santomé JA.
    Journal: Int J Pept Protein Res; 1985 Dec; 26(6):568-74. PubMed ID: 3937819.
    Abstract:
    Bovine growth hormone was modified by reaction with 1,5-difluoro-2,4-dinitrobenzene under conditions favouring production of intramolecularly crosslinked derivatives from monomeric molecules. The monomeric fraction, isolated by chromatography on Sephadex G-100, was oxidized or reduced and carbamidomethylated and trypsin digested. The resulting peptides were fractionated on SP-Sephadex and further purified by peptide mapping or HPLC. Two modified peptides containing sequences 108-112 or 108-113 and 171-176 of bGH were obtained, including a dinitrophenylene bridge between lysine 111 and tyrosine 174, thus suggesting the stereochemical proximity of these residues.
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