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  • Title: Transplantation of amniotic epithelial membranes in patients with mucopolysaccharidoses.
    Author: Akle C, McColl I, Dean M, Adinolfi M, Brown S, Fensom AH, Marsh J, Welsh K.
    Journal: Exp Clin Immunogenet; 1985; 2(1):43-8. PubMed ID: 3939973.
    Abstract:
    This paper reports the biochemical results of transplanting human amniotic epithelial cells in 3 children with Hunter's and 2 with Hurler's disease. A transient and modest increase of alpha-L-idurono-2-sulphate sulphatase or alpha-iduronidase was observed in the white cells collected from 1 patient with Hunter's and 1 with Hurler's disease. No variation in the excretion of glycosaminoglycans or oligosaccharides was detected in all 5 patients. There was no evidence of immune response towards the transplanted cells or the specifically deficient enzyme. Thus, in spite of the absence of the major histocompatibility antigens, HLA A, B, C and DR, on the surface of the amniotic epithelial cells, no long-term correction of lysosomal enzyme deficiencies was achieved by transplanting amniotic epithelial membranes collected at the end of the gestational period.
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