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  • Title: Evaluation of the Eazyplex®Candida ID LAMP Assay for the Rapid Diagnosis of Positive Blood Cultures.
    Author: Berlau A, Stoll S, Edel B, Löffler B, Rödel J.
    Journal: Diagnostics (Basel); 2024 Sep 25; 14(19):. PubMed ID: 39410532.
    Abstract:
    Rapid molecular assays can be used to identify Candida pathogens directly from positive blood cultures (BCs) in a timely manner compared to standard methods using subcultures. In this study, the eazyplex®Candida ID assay, which is based on loop-mediated amplification (LAMP) and is currently for research use only, was evaluated for the identification of the most common fungal species. A total of 190 BCs were analysed. Sensitivity and specificity were 93.88% and 99.26% for C. albicans, 89.13% and 100% for Nakaseomyces glabratus (N. glabratus), 100% and 100% for Pichia kudravzevii (P. kudriavzevii), 100% and 100% for C. tropicalis, and 100% and 99.44% for C. parapsilosis. Sample preparation took approximately 11 min and positive amplification results were obtained between 8.5 and 19 min. The eazyplex®Candida ID LAMP assay is an easy-to-use diagnostic tool that can optimise the management of patients with candidemia.
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