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  • Title: Gentamicin dosage recommendations for neonates based on half-life predictions from birthweight.
    Author: Charlton CK, Needelman H, Thomas RW, Kortas K.
    Journal: Am J Perinatol; 1986 Jan; 3(1):28-32. PubMed ID: 3942611.
    Abstract:
    The appropriate dosing of gentamicin in the newborn was evaluated. Gentamicin was administered intramuscularly to 151 neonates ranging in birthweight from 0.66 to 4.7 kg (gestational age, 26-42 weeks) during a 7-month period. A dosage of 2.5 mg/kg of birthweight every 12 hours was initiated at birth until gentamicin serum levels could be determined. These infants were divided into three groups based on birthweight: 1) less than or equal to 1000 gm; 2) 1001-2000 gm; 3) greater than 2000 gm. From gentamicin serum level data, these three groups had significantly different (P less than 0.05) gentamicin half-lives. Based on the desirability of maintaining a trough gentamicin serum level less than 2, 100, 95.5, and 39% of infants in groups 1, 2, and 3, respectively, required initial dosing interval adjustments. A second group of 74 infants whose birthweight ranged from 0.82 to 3.9 kg (gestational age, 26-42 weeks) required aminoglycoside therapy and were prospectively placed on gentamicin 2.5 mg/kg of birthweight on the following schedule: 1) less than or equal to 1000 gm every 24 hours; 2) 1001-2000 gm every 18 hours; 3) greater than 2000 gm every 12 hours. Using this method, only 15, 58, and 33% of infants in groups 1, 2, and 3, respectively, required dosing interval changes. We conclude that a marked reduction in undesirably high trough gentamicin serum levels can be affected by a simple change in dosing interval based on birthweight, although gentamicin serum levels are still required due to a significant number of infants with high trough levels.
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