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  • Title: Effects of combined extradural blockade and general anaesthesia on indocyanine green clearance and halothane metabolism.
    Author: Nancarrow C, Plummer JL, Ilsley AH, McLean CF, Cousins MJ.
    Journal: Br J Anaesth; 1986 Jan; 58(1):29-36. PubMed ID: 3942667.
    Abstract:
    Cardiovascular effects, indocyanine green clearance and the reductive metabolism of halothane were compared in 10 patients having peripheral surgery who received either general anaesthesia or general anaesthesia plus extradural blockade. Bupivacaine or saline was given extradurally 1 h before anaesthesia with nitrous oxide:oxygen (70:30) and halothane (end-tidal concentration 0.35%). Indocyanine green clearance was measured before (stage I) and after (stage II) bupivacaine or saline, during anaesthesia before surgery (stage III), and during surgery (stage IV). Reductive metabolism of halothane was assessed by measurement of exhaled 2-chloro-1,1,1-trifluoroethane. In the general anaesthesia plus extradural blockade group, arterial pressure was decreased to 58% (SD = 6) of stage I values over stages II-IV, whereas no changes were observed in the general anaesthesia group. There was no significant difference in indocyanine green clearance or the reductive metabolism of halothane, despite the occurrence of significant decreases in arterial pressure.
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