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  • Title: [Isolation and analysis of monoclonal antibodies against various gangliosides].
    Author: Fuks BB, Avrova NF, Van'ko LV, Starosvetskaia NA, Boltovskaia MN.
    Journal: Biull Eksp Biol Med; 1986 Jan; 101(1):66-8. PubMed ID: 3942818.
    Abstract:
    Female BALB/c mice were immunized with human melanoma (Mewo) cells containing ganglioside GD3 as a surface antigen. Immune splenocytes were fused with syngeneic P3-X63.Ag 8 myeloma cells. Antibodies produced by hybrid clones were analyzed by solid phase immunoassay. B, C, D and Q clones producing antibodies against Raja clavata brain gangliosides were obtained. Monoclonal B and C antibodies bound monosialogangliosides. Monoclonal D antibody bound a number of gangliosides but reacted predominantly with GD1a. Monoclonal Q antibody reacted selectively with GQ1c. It is assumed that ganglioside GQ1c is expressed on the melanoma cell surface and may be found only in the early stage of ontogenesis of high vertebrates.
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