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  • Title: A possible etiological role for ascorbate in calculi formation.
    Author: Chalmers AH, Cowley DM, Brown JM.
    Journal: Clin Chem; 1986 Feb; 32(2):333-6. PubMed ID: 3943193.
    Abstract:
    Studies of recurrent stone formers indicated that they have significantly increased urinary oxalate and decreased ascorbate excretions. Results of oral and intravenous administration of ascorbate indicate an enhanced production of oxalate from ascorbate in recurrent calcium stone formers as compared with normal persons and that most of this oxalate is generated in the gut.
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