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  • Title: Facilitated transport of 3-O-methyl-D-glucose in human polymorphonuclear leukocytes.
    Author: Okuno Y, Plesner L, Larsen TR, Gliemann J.
    Journal: FEBS Lett; 1986 Jan 20; 195(1-2):303-8. PubMed ID: 3943614.
    Abstract:
    Transport of the nonmetabolizable hexose analogue 3-O-methyl-D-glucose (30MG) was measured in human polymorphonuclear leukocytes at 37 degrees C, pH 7.4. 3OMG at very low concentration (0.05 mM) equilibrated with the intracellular water with a rate constant of about 0.08 s-1. Transport of 3OMG in the presence of 20 microM cytochalasin B and transport of L-glucose were insignificant. Countertransport of 14C-labelled 3OMG was demonstrated. Exchange of 3OMG between the extracellular and intracellular water showed saturation with a Km of about 4 mM. Thus, the transport of 3OMG is mediated almost exclusively by facilitated diffusion.
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