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  • Title: New data on clonal anomalies of chromosome 14 in ataxia telangiectasia: tct(14;14) and inv(14).
    Author: Aurias A, Croquette MF, Nuyts JP, Griscelli C, Dutrillaux B.
    Journal: Hum Genet; 1986 Jan; 72(1):22-4. PubMed ID: 3943860.
    Abstract:
    From a series of 53 patients with ataxia telangiectasia, two large clones with a t tan or tct(14;14) and two with an inv(14) were observed among phytohaemagglutinin (PHA)-stimulated lymphocytes. Smaller clones with the same inv(14) were observed in two other cases. Similar breakpoints may exist, both for t(14;14) and inv(14): q11.1/q11.2 and q32, and it is postulated that the rearrangements are related to a recombination of the alpha-chain of the T-cell receptor and IgH clusters of genes.
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