These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Lack of relationship between serum gp70 levels and the severity of systemic lupus erythematosus in MRL/l mice.
    Author: Andrews J, Hang L, Theofilopoulos AN, Dixon FJ.
    Journal: J Exp Med; 1986 Feb 01; 163(2):458-62. PubMed ID: 3944541.
    Abstract:
    In the MRL/l mouse, gp70 apparently plays a role as an autoantigen in the development of SLE. However, while gp70 may be an important pathogenetic element, it is not essential to MRL SLE, since elimination of most of the serum gp70 and virtually all of the immune complex gp70 from MRL/l-low gp70 congenic lines had no observable effect on the course or nature of the disease. Thus, while gp70 in the MRL/l mouse appears to be a convenient autoantigenic target when present in significant levels, in its absence the host appears capable of directing its aberrant immunologic responsiveness elsewhere with undiminished pathogenicity.
    [Abstract] [Full Text] [Related] [New Search]