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  • Title: Prolactin-secreting pituitary adenoma in a man with gigantism: a case report.
    Author: Peillon F, Philippon J, Brandi AM, Fohanno D, Laplane D, Dubois MP, Decourt J.
    Journal: Acta Endocrinol (Copenh); 1979 Dec; 92(4):627-39. PubMed ID: 394552.
    Abstract:
    A prolactin-secreting pituitary adenoma was removed trans-sphenoidally from a 37 years old man with gigantism (218 cm). Serum levels of prolactin (PRL) were elevated pre-operatively and decreased after administration of L-Dopa with no increase after TRH as is usually observed in PRL-secreting adenomas. Growth hormone (GH) and somatomedin serum levels were normal with no modification of GH after insulin hypoglycemia, oral glucose loading or L-Dopa. Morphological examination of the tumour demonstrated the presence of lactotrophs by light and electron microscopy and by immunofluorescense staining. No somatotrophs were found. In this unique case, the relationship between a PRL-secreting adenoma and gigantism is discussed.
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