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  • Title: Starvation increases the solubility of volatile anaesthetics in rat liver.
    Author: Fassoulaki A, Eger EI.
    Journal: Br J Anaesth; 1986 Mar; 58(3):327-9. PubMed ID: 3947496.
    Abstract:
    We evaluated the effect of starvation on anaesthetic solubility in tissues involved in lipid transport (blood) or metabolism (liver) and in a tissue not involved in either (brain). The liver/gas partition coefficients of isoflurane, enflurane, halothane and methoxyflurane in rats increased by 15-20% after 6 h of starvation and reached a maximum increase of 35-42% after 24 h of starvation. After 48 h of starvation the coefficients had returned to control values. Blood/gas and brain/gas partition coefficients were not changed or were inconsistently changed by starvation. The maximum change in blood or brain solubility was 14% (at 6 h), and 29 of 32 mean values changed less than 10%.
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