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  • Title: Role of chloride on carrier-mediated transport of p-aminohippurate in rat renal basolateral membrane vesicles.
    Author: Inui K, Takano M, Okano T, Hori R.
    Journal: Biochim Biophys Acta; 1986 Mar 13; 855(3):425-8. PubMed ID: 3947632.
    Abstract:
    Effect of inorganic anions on p-amino[3H]hippurate transport in renal basolateral membranes has been studied using the vesicles preloaded with unlabeled p-aminohippurate (countertransport condition). The uptake of p-amino[3H]hippurate was stimulated by the outward gradient of unlabeled p-aminohippurate and the labeled substrate was accumulated into the vesicles against its concentration gradient in the presence of Cl-. The substitution of SCN- and SO4(2-) for Cl- in both sides of the vesicles depressed the initial rate and the overshoot magnitude of p-amino[3H]hippurate uptake. These results suggest that Cl- may play an important role for the carrier-mediated transport system of organic anion in renal basolateral membranes.
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