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  • Title: Gonadal tumor and H-Y antigen in 46,XY pure gonadal dysgenesis.
    Author: Amice V, Amice J, Bercovici JP, Riviere D, Corolleur MJ.
    Journal: Cancer; 1986 Apr 01; 57(7):1313-7. PubMed ID: 3948114.
    Abstract:
    Six cases of Swyer's syndrome (46,XY pure gonadal dysgenesis) are reported. Three patients, without gonadal tumor, had female H-Y antigen. Three patients, after gonadal tumor ablation, had intermediate H-Y antigen levels. Repeated blood samples were obtained from two siblings. H-Y antigen level in the first sibling, who presented with a gonadoblastoma and underwent a gonadectomy before the H-Y assays, was intermediate, and did not show any significant variation for 21 months. H-Y antigen level in the second sibling showed an increase in the male range, presumably due to the presence of gonadoblastomas. After resection of the tumors, H-Y antigen level became intermediate. These findings suggest a relation between the tumorization potentiality of the gonadal remnants and the H-Y antigen levels in 46,XY pure gonadal dysgenesis.
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