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  • Title: [Effect of rutin and esculamine on models of aseptic inflammation].
    Author: Aleksandrov PN, Speranskaia TV, Bobkov IuG, Zagorevskiĭ VA, Zykov DA.
    Journal: Farmakol Toksikol; 1986; 49(1):84-6. PubMed ID: 3948995.
    Abstract:
    It was shown in experiments on rats that intraabdominal administration of silver nitrate solution induces peritonitis and the subplantar administration of histamine, serotonin and prostaglandin E2 leads to an acute paw edema. Preliminary subcutaneous administration of esculamine or rutin inhibited the development of the inflammation. Esculamine proved more active here.
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